TITLE: Multimodal Imaging of Pathophysiological Changes and Their Role in Development of Breast Cancer Brain Metastasis PRINCIPAL INVESTIGATOR:

Published Conference Proceedings): 1) Heling Zhou, Am yn Habib, Peter Antich, Ra lph P. Mason, Dawen Zhao. In vivo Imaging of Tum or Hypoxia and Vasculatur e of Orthotopic Mouse Brain Tum or Models. Journal of Nuclear Medicine, Vol. 51, p830, 2010. Employment or research opportunity: The PhD student and research assistant, Heling Zhou, continues to work on this project. Conclusion: During the second year of this pro ject, we have established a new mouse model o f breast cancer brain metastases. Multiple intracrania l tumor lesions can b e achieved using this intracardiac model. No n-invasive BLI and MR I have be en performe d for early detection a nd tumor follow up. Interest ing results of in vivo imaging suggest characteristic vascular perfusion in these br ain metastases, which may pro vide us eful information to facilitate differential diagnosis. Taken together, the first and second year research has built a strong fou ndation for further evaluation of tumor response to therapeutics.